DENVER (AP) — The Denver Broncos overcame a short week, an early alarm, a slow start and a 14-point fourth-quarter deficit to beat the reigning champions for their biggest win since Super Bowl 50 nearly a decade ago.

Their 21-17 stunner at Philadelphia marked just the second time in 114 road games that the Broncos trailed by 14 or more points entering the fourth quarter and ended up winning the game.

The only other time that happened was in Week 4 in 2023, when Denver overcame a 28-14 deficit to beat Chicago 31-28 and give coach Sean Payton his first win with Broncos.

Now, he's got his signature win with Denver, as does second-year quarterback Bo Nix.

The Broncos trailed the Eagles 17-3 heading into the fourth quarter Sunday after punting on seven of their eight drives. The outlier was a 12-play, 32-yard field-goal drive in the first quarter.

Denver's defense, however, shut down the Eagles over their final five drives and gave Nix & Co. the opening for a comeback. Nix led a pair of touchdown drives, the second of which ended with a 2-point conversion when Troy Franklin jab stepped with his left foot and was open for Nix's pass to give Denver an 18-17 lead and silence the crowd at Lincoln Financial Field.

“I wasn’t surprised" by Payton's 2-point call, Nix said. "Next thing I knew he was just giving the hash, gave me the call, and we had one play to go get the job done. Troy ran a great route. We’ve been practicing that for a couple of weeks, and he got in the end zone. I mean just trust in his players and we got the job done.”

The Eagles never recovered, losing at home for the first time in more than a year.

“After the 2-point (try), we just got some great momentum and we just played with that for the rest of the game,” said Nix, who added a clock-chewing, 11-play drive that covered 50 yards and ended with Wil Lutz's second field goal.

Then, it was up to Vance Joseph's defenders to close things out, which they did when cornerback Patrick Surtain II knocked away Jalen Hurts' desperation heave into the end zone from the Denver 29 as time expired.

The comeback made for an enjoyable trip across the Atlantic as the Broncos took a red-eye flight to London, where they'll face the winless Jets (0-5) on Sunday.

“It’s awesome. It’s a great win. It proves that we can go on the road and beat these tough teams and we can be a tough team to play," Nix said. "So that’s good for our confidence. It’s good for going on this trip. A lot of teams struggle before they go to London, but we focused on this trip, we focused on this game and we went out and got it done. It was good for us.”

What’s working

Rookie punter Jeremy Crawshaw got a good workout through three quarters, punting seven times and pinning the Eagles inside their 15-yard line five times. He helped the Broncos win field position on an afternoon when it proved crucial.

What needs help

Safety J.L. Skinner had one pass interference penalty on Philadelphia's final drive and easily could have been whistled for another on an incompletion near the goal line with 9 seconds left.

Stock up

Bo Nix the closer. In the fourth quarter he was 9 for 10 for 126 yards and a touchdown. He led three scoring drives as Denver scored 18 unanswered points.

Stock down

Bo Nix the starter. Through three quarters, he was 15 for 29 for 116 yards and no touchdowns as Denver punted seven times and gained a net 145 yards.

Injuries

Left guard Ben Powers flew to Denver instead of London after the game so he can get tests on his injured biceps. Also staying behind was QB2 Jarrett Stidham, whose wife is expecting the couple's third child. Stidham is expected to rejoin the team later in the week.

Key stats

Nik Bonitto registered 2 1/2 sacks, giving him an NFL-best seven through five games. The Broncos finished with six sacks, giving them a league-high 21 a year after they collected a franchise-record 65 quarterback takedowns.

Next steps

The Broncos can bring home a 4-2 record by taking care of business in London.

Trevor Lawrence's heroic touchdown caps NFL's record-tying week of double-digit comebacks

Not even three-time Super Bowl champion Patrick Mahomes was immune to the colossal comebacks that defined Week 5 in the NFL.

Trevor Lawrence rallied Jacksonville from a 14-0 deficit and scored the winning touchdown after getting stepped on by his right guard, falling back down, getting back up, slipping a tackle and diving into the end zone to give the Jaguars a wild 31-28 win over the mistake-prone Kansas City Chiefs on Monday night.

“It (stinks) when you get a lead like that and you're not able to hold it throughout the rest of the game,” Mahomes said after the Chiefs, who went 11-0 in one-score games last season, fell to 0-3 in such games this season.

The Eagles, Cardinals, Dolphins, Giants and Chargers knew exactly how Mahomes felt.

They also let double-digit leads slip away in Week 5 when a record-tying six teams lost after leading by double digits.

The six-pack of double-digit comebacks — or pratfalls, if you prefer — marked the sixth week in NFL history in which a half dozen teams had comeback wins after trailing by double digits.

It also happened in 1984, 1999, 2002, 2011 and 2013.

The Chiefs had been 62-4 in games with Mahomes at QB after leading by 14-plus points and their loss at Jacksonville snapped a 23-game winning streak in which they led by 14 or more points, dating to the 2021 AFC championship.

The Jaguars joined the Broncos, Commanders, Panthers, Titans and Saints in roaring back after falling behind big.

The Broncos handed the reigning Super Bowl champion Philadelphia Eagles their first loss by overcoming a 17-3 deficit with 18 unanswered points in the fourth quarter. Denver improved to 2-112 on the road when entering the fourth quarter trailing by 14-plus points.

Cam Ward got his first career win by rallying the Titans back from a 18-point deficit to beat Arizona 22-21.

The Panthers overcome a 17-point deficit to beat Miami 27-24; the Saints overcome an 11-point deficit to beat the New York Giants 26-14 and the Commanders clawed back from a 10-point hole by scoring 27 unanswered points against the Chargers.

Another defining moment in the Jaguars' comeback aside from Lawrence's eventful game-winning touchdown run was linebacker Devin Lloyd's 99-yard pick-six that broke a 14-14 tie.

Lloyd jumped the route at the 1 and eluded a diving Mahomes at the Jacksonville 12 on his way down the sideline to the end zone for the longest play in the NFL so far this season.

The Chiefs fell to 2-3. They didn't suffer their third loss last year until they were walloped 40-22 by the Eagles in the Super Bowl.

Apparel peril

The wacky weekend began with San Francisco's 26-23 overtime win against the Los Angeles Rams on Thursday night — which featured an early 14-0 lead for the 49ers before the Rams made a game of it.

The photo op might make business sense — Stan Kroenke owns the Rams and Avalanche along with the NBA's Denver Nuggets — but it was a public relations landmine considering the social media backlash it engendered.

“To be honest, I understand it,” Avalanche captain Gabriel Landeskog said Monday. "Colorado fans are passionate. To me, I didn't watch the NFL until I came here in 2011. The Broncos are my team. That'll never change.

“But when the big boss invites you to come watch the Rams game and the way he took care of us there, you know it is a special bond for us to be a part of not just of the Avs and the Nuggets and the Mammoth but to be a part of the broader Kroenke Sports family, you know, the Rams and (soccer club) Arsenal overseas, it's special,” Landeskog added.

“It was really a cool experience. Who would turn that down?" Landeskog said, adding, “for one night I think you can cheer on a team and it doesn't change how you feel about whoever your primary team is.”

This NFL-NHL fashion faux pas brought to mind Texans quarterback C.J. Stroud, who caught flack in August for wearing a Seattle Mariners cap before and after a preseason game against Carolina.

“I love hats,” Stroud explained back in August. “I probably have every team. But I support the Astros and the Dodgers — because I'm from L.A. ... but it's all about the swag, baby!”